The BIP Monoclonal Antibody (Clone AT3D2) from IBL- America is a Mouse Monoclonal antibody to HSPA5. This antibody recognizes Homo Sapiens, and Human antigen. The BIP Monoclonal Antibody (Clone AT3D2) has been validated for the following applications: EIA, Immunoassay, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Binding immunoglobulin protein (BIP) also known as 78kDa glucose-regulated protein(GRP-78) or heat shock 70kDa protein 5(HSPA5) is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum(ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BIP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. BIP is an abundant protein under all growth conditions, but its synthesis is markedly induced under conditions that lead to the accumulation of unfolded polypeptides in the ER